Canada
Late 1990S
De Simone Formulation developed by Professor Claudio De Simone.
2003
De Simone Formulation Launched in the US. [[[VSL#3® is a registered trademark and is manufactured exclusively for, VSL Pharmaceuticals, Inc. Visbiome® is manufactured exclusively for ExeGi Pharma, LLC and is not affiliated with, endorsed by, or distributed by VSL Pharmaceuticals, Inc. ExeGi Pharma, LLC and VSL Pharmaceuticals, Inc. are different companies and have no affiliation with each other.]]](((https://visbiome.com)))
Mayo Clinic publishes first De Simone Formulation trial in dietary management of IBS.[[[Gionchetti P, et al. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double blind, placebo-controlled trial. Gastroenterology. 2000;119(2):305-309]]](((https://visbiome.com)))
2004
De Simone Formulation citied in American Journal of Gastroenterology Practice Guidelines for pouchtis.[[[Kim HJ, et al. A randomized controlled trial of a probiotic, VSL#3®*, on gut transit and symptoms in diarrhea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2003; 17:895-904.]]](((https://visbiome.com)))
2005
First major in dietary management of ulcerative colitis. Bibiloni 2005.[[[Kornbluth et al. Ulcerative Colitis Practice Guidelines in Adults (Update) American College of Gastroenterology, Practice Parameters Committee. Am. Coll. Of Gastroenterology. 2004]]](((https://visbiome.com)))
2008
European Crohn’s and Colitis Organisation (ECCO) recognizes De Simone Formulation in guidelines.[[[Bibiloni, et al. VSL#3®* probiotic-mixture induces remission in patients with active ulcerative colitis. Am J Gastroenterol. 2005; 100:1539-1546.]]](((https://visbiome.com)))
2010
First pediatric IBS study published.[[[Biancone et al. European evidence-based Consensus on the management of ulcerative colitis. Journal of Crohns and Colitis. 2008]]](((https://visbiome.com)))
2015
Over 70 clinical trials published on the De Simone Formulation.
2016
De Simone Formulation launched as Visbiome in the U.S.
Visbiome approved by Health Canada as Natural Health Product.
2018
Visbiome Vet launched in U.S.
2019
Cochrane Review recognizes De Simone Formulation pouchitis clinical guidelines.[[[Barnes et al. AGA Clinical Practice Guidelines on the Management of Pouchitis and Inflammatory Pouch Disorders. Gastroenterology. 2024]]](((https://visbiome.com)))
2023
Visbiome passes 8,000 5-star reviews.
2024
Visbiome Recognized by AGA – Treatment Guidelines for pouchitis.[[[Visbiome GI Care products are medical food products. Visbiome Infant Drops is a dietary supplement. (Certain products have 8 strains and are powered by the De Simone Formulation.)]]](((https://visbiome.com)))